How does aspirin worsen asthma

Some content may no longer be current. Termed aspirin-induced asthma, this reaction is potentially fatal. Asthmatics with chronic rhinitis or a history of nasal polyps are at greater risk. The reaction rarely occurs in children. Patients initially present with an acute episode of vague malaise, sneezing, nasal obstruction, rhinorrhoea and often a productive cough. COX-1 is the constitutive enzyme responsible for synthesis of protective prostanoids, whereas COX-2 is induced under inflammatory conditions.

A number of theories regarding its pathogenesis have been proposed. The shunting hypothesis proposes that inhibition of COX-1 shunts AA metabolism away from production of protective prostanoids and towards cysteinyl leukotriene cys-LT biosynthesis, resulting in bronchoconstriction and increased mucus production. The COX-2 hypothesis proposes that aspirin causes a structural change in COX-2 that results in the generation of products of the lipoxygenase pathway. Nasal polyps. Updated June 28, Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system [published correction appears in Proc Natl Acad Sci U S A.

Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. Aspirin challenge and desensitization: how, when and why. Curr Opin Allergy Clin Immunol. Could eosinophilia predict clinical severity in nasal polyps? Multidiscip Respir Med. Long-term sinonasal outcomes of aspirin desensitization in aspirin exacerbated respiratory disease.

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I Accept Show Purposes. Table of Contents View All. Table of Contents. People with more serious cases are at higher risk. Asthma Doctor Discussion Guide Get our printable guide for your next doctor's appointment to help you ask the right questions.

Download PDF. Email the Guide Send to yourself or a loved one. Sign Up. How Asthma Is Diagnosed. How Asthma Is Treated. Don't Try This At Home You should never attempt aspirin desensitization without medical supervision, as it could trigger a severe and potentially fatal asthmatic reaction. Benefits and Risks of Opioids for Chronic Pain.

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